Companies of all sizes rely on predictable and reliable intellectual property (IP) frameworks. The European Union has proposed changes to the Compulsory Licensing (CL) Regulation in order to address the existing gaps in Europe’s IP environment.  As the trilogues on the Regulation begin, the American Chamber of Commerce to the EU wishes to highlight key concerns with the current text of the regulation, specifically with the position of the European Parliament. Although the European Parliament’s position seeks to include certain safeguards on trade secrets, strong concerns remain regarding the potential mandatory disclosure of trade secrets and know-how. If implemented, such disclosures would irrevocably harm innovators. AmCham EU urges policymakers to take these considerations into account, as well as others outlined in the letter, to ensure a fairer and more workable IP system in Europe.